Gut bacteria may play a role in diabetes mellitus development

Gut bacteria may play a role in diabetes mellitus development

Major Gheorghe GIURGIU¹,Prof dr Manole COJOCARU^2,3

¹Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania

deniplant@gmail.com; Telephone: +40 744 827 881

https://orcid.org/0000-0002-5449-2712

²Academy of Romanian Scientists

³Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania

cojocaru.manole@gmail.com; Telephone: +40 723 326 663
https://orcid.org/0000-0002-7192-7490

Background The gut microbiota has been identified as a potential contributor to diabetes. Studies in the past ten years have shown that low-grade inflammation has an important role in the molecular mechanism of diabetes mellitus. Obesity and diabetes are long known for being mainly influenced by a positive balance between food intake and energy expenditure.

Objectives To determine whether modulating these bacteria (via prebiotics, probiotics, or antibiotics, depending on the bacterial targets) using Imuniplant is a viable option to prevent or treat diabetes.

Materials and methods The gut microbiota plays an important role in the development of the immune system and helps maintain the intestinal homeostasis. The gut microbiota is easily altered by dietary changes. 

Results The gut microbiota plays a pivotal role in the body’s metabolism and immunity responses can also become a regulator of the effect of diet on the host’s metabolic state. Current research continues to find associations between microbiota and diabetes, and these appear to involve many metabolic effects and immune response processes, and most of these associate with more specific mechanisms. Dietary changes have been shown to have significant effects on the gut microbiota. 

Conclusion Gut microbiota composition also varies with an individual’s age, and studies have shown these age-related gut microbiota changes could possibly occur due to changes in diet at different ages and changes in inflammation due to some age-related diseases and changes leading to decreased immune system function. It appears that the human oral and gut microbiota are deeply interdigitated with diabetes. 

Keywords gut microbiota, inflammation, diabetes, Imuniplant