Gut-brain axis: How the microbiome influences anxiety and depression

Gut-brain axis: How the microbiome influences anxiety and depression

Major Gheorghe GIURGIU¹,Prof. dr. Manole COJOCARU^2,3

¹Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania

deniplant@gmail.com; Telephone: +40 744 827 881

https://orcid.org/0000-0002-5449-2712

²Academy of Romanian Scientists

³Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania

cojocaru.manole@gmail.com; Telephone: +40 723 326 663
https://orcid.org/0000-0002-7192-7490

Background Studies have shown that our gut health and the health of our gut bacteria can have a substantial influence on our mental well-being. A number of important functions performed by the gut microbiome are well recognized including the digestion of polysaccharides, biosynthesis of vitamins and nutrients, colonization resistance, and immune system modulation 

Objectives The functional profiles in the gut microbiome can be perturbed by additives. The role of additives in gut microbiome toxicity still remains underappreciated. With our expertise we’ve evaluated Antistress tea, examined how diet and anxiety reciprocally interact with the gut microbiota and inflammation and reviewed different interventions that can modulate microbiota and could modulate the anxiety according to the underlying mechanisms whereby the gut-brain axis influences anxiety.

Materials and methods The human gut microbiome can be easily disturbed upon exposure to a range of additives. In fact, the gut bacteria play an important role in the biotransformation of additives. Food additives can cause worsening intestinal inflammation.

Results Environmentally induced perturbation in the gut microbiome is strongly associated with human disease risk.  These additives induced perturbations are potentially linked to elevated disease risks. Inflammatory bowel disease, obesity, diabetes, cardiovascular disease, liver disease, colorectal cancer, and neurological disorders can be at least in part attributed to undesirable functional alterations in the gut microbiome 

Conclusion The human gut microbiome has received unprecedented attention over the past decade. The exposure to various additives leads to functional perturbation in the gut microbiome. Healthier diets can reduce the risk of anxiety.

Keywords: gut microbiome, additives, anxiety, Antistress Tea