Gut microbiome and metabolites in rheumatoid arthritis:Link, mechanisms and Deniplant intervention
Major Gheorghe GIURGIU1,Prof dr Manole COJOCARU2,3
1Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania
deniplant@gmail.com; Telephone: +40 744 827 881
2Academy of Romanian Scientists
3Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania
cojocaru.manole@gmail.com; Telephone: +40 723 326 663
https://orcid.org/0000-0002-7192-7490
Background Rheumatoid arthritis is a chronic, complex and systemic autoimmune disease. Dysbiosis of the intestinal microbiome is a vital environmental element that triggers the onset of rheumatoid arthritis, and dysregulation of the microbiome may result in abnormal immune responses.
Objective An intricate relationship between gut microbiome changes and metabolic alterations could help explain the mechanisms by which gut bacteria play roles in the pathogenesis of rheumatoid arthritis. To arrive at these observations, we examined how Deniplant intervention solve disabilities in rheumatoid arthritis, to demonstrate role of Imuniplant, and Artropol in the management of rheumatoid arthritis.
Materials and methods Currently, disturbance of the gut microbiota has emerged as a novel player involved in the pathogenesis of rheumatoid arthritis. With in-depth research, the understanding of the intestinal bacteria-host interaction in rheumatoid arthritis is much more comprehensive.
Results A well-functioning immune system is critical for survival. The oral and intestinal microbiomes have a role in the development of rheumatoid arthritis. Recent years have also seen an increase in metabolomics studies in rheumatoid arthritis with the attempt to identify potential biomarkers for diagnosis or disease activity monitoring. Here, we reviewed the role of microbiota dysbiosis in the aetiology of rheumatoid arthritis.
Conclusion A proposed treatment strategy for rheumatoid arthritis based on gut microbiome regulation is also discussed in this study. Increasing our understanding of gut microbiota and their function in rheumatoid arthritis will provide us with novel opportunities to develop effective and precise diagnostic strategies and to explore potential microbiota-based treatments for patients with rheumatoid arthritis.
Keywords rheumatoid arthritis, gut microbiota, immune response, inflammation, Deniplant intervention