WHAT WE KNOW ABOUT PSORIASIS SO FAR?
Major Gheorghe GIURGIU1,Prof. dr. med. Manole COJOCARU2,3
1Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania
deniplant@gmail.com; Telephone: +40 744 827 881
2Academy of Romanian Scientists
3Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania
cojocaru.manole@gmail.com; Telephone: +40 723 326 663
https://orcid.org/0000-0002-7192-7490
Background Restoration of the dysbiotic gut microbiome has emerged as a promising aid and a better therapeutic approach.
Objective New evidences suggest that the microbiome may play a pathogenic role in psoriatic disease. The aim of the present project is to investigate whether a dietary intervention could ameliorate the clinical manifestations and modulate the gut microbiota of individuals with psoriasis.
Materials and methods Nutrition plays an important role in the development of psoriasis and it can modulate microbiome composition.
Results Among environmental factors, diet plays a central role therefore incorrect nutritional habits and excessive body weight can increase clinical symptoms or even trigger the disease. Such diet-based and nutraceutical approaches to targeting the microbiome may produce a milder side effect profile than current systemic medications. Thus, interventions aimed at the microbiome may be a valuable adjunct for preventing or managing psoriatic disease and its comorbidities.
Conclusion Nutrition plays an important role in the development of psoriasis and its comorbidities. Ultimately, a better understanding of the psoriatic microbiome can lead to the development of new therapeutic modalities that target the shifting microbiota. Thus, interventions aimed at the microbiome may be a valuable adjunct for preventing or managing psoriatic disease and its comorbidities.
Keywords: psoriasis, microbiome, microbiota, Deniplant nutraceuticals